An inhibitor of dipeptidase (dehydropeptidase I); inhibits human renal dipeptidase (Ki = 0.7 μM)

Cilastatin – 250 mg

Brand:
Cayman
CAS:
82009-34-5
Storage:
-20
UN-No:
Non-Hazardous - /

Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase.{36366} It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM).{36366,36367,36368} Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin (Item No. 15327).{36369} In a mouse model of systemic infection, cilastatin in combination with imipenem (Item No. 16039) protects mice from S. aureus, E. coli, and P. aeruginosa infection.{36370} Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life.{36367} Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections.  

 

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SKU: 23511 - 250 mg Category:

Description

An inhibitor of dipeptidase (dehydropeptidase I); inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM); protects primary porcine renal proximal tubular epithelial cells from vancomycin-induced nephrotoxicity and apoptosis (200 μg/ml); protects mice from systemic infection by S. aureus, E. coli, and P. aeruginosa when administered in combination with imipenem; inhibits renal metabolism of imipenem to prolong its half-life

Formal name: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid

Synonyms: 

Molecular weight: 358.5

CAS: 82009-34-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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