A fungal metabolite with diverse biological activities; reduces melanin production in Mel-Ab mouse melanocytes in a dose-dependent manner via ERK activation and downregulation of MITF; inhibits proliferation of human keratinocytes and thins the epidermis in a skin equivalent model of psoriasis vulgaris; inhibits growth of various bacteria and fungi (MICs = 1-40 μg/ml); inhibits growth of A549 lung cancer cells in a dose-dependent manner

Terrein – 5 mg

Brand:
Cayman
CAS:
582-46-7
Storage:
-20
UN-No:
Non-Hazardous - /

Terrein is a fungal metabolite produced by A. terreus with diverse biological activities.{36169} It reduces melanin production in Mel-Ab mouse melanocytes in a dose-dependent manner via ERK activation and downregulation of microphthalmia-associated transcription factor (MITF).{36170} Terrein inhibits proliferation of human keratinocytes and thins the epidermis in a skin equivalent model of psoriasis vulgaris.{36171} It is antimicrobial, inhibiting the growth of S. aureus, A. hydrophila, E. faecalis, A. flavus, A. alternata, B. sorokiniana, and P. drechsleri (MICs = 1-40 μg/ml).{36172} Terrein also inhibits growth of A549 lung cancer cells in a dose-dependent manner.  

 

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SKU: 23496 - 5 mg Category:

Description

A fungal metabolite with diverse biological activities; reduces melanin production in Mel-Ab mouse melanocytes in a dose-dependent manner via ERK activation and downregulation of MITF; inhibits proliferation of human keratinocytes and thins the epidermis in a skin equivalent model of psoriasis vulgaris; inhibits growth of various bacteria and fungi (MICs = 1-40 μg/ml); inhibits growth of A549 lung cancer cells in a dose-dependent manner

Formal name: 4S,5R-dihydroxy-3-(1E)-1-propen-1-yl-2-cyclopenten-1-one

Synonyms:  NSC 291308

Molecular weight: 154.2

CAS: 582-46-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Epigenetics, Transcription, & Translation||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Infectious Disease|Bacterial Diseases

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