A cyclic dipeptide; used as a substrate for indole prenyltransferases in the synthesis of mono- and diprenylated indolines; inhibits growth of 41 out of 49 strains of multidrug resistant A. baumannii (MICs = 12.5-25 µg/ml) as well as B. subtilis

Cyclo(L-Trp-L-Trp) – 250 mg

Brand:
Cayman
CAS:
20829-55-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclo(L-Trp-L-Trp) is a cyclic dipeptide that has been used as a substrate for indole prenyltransferases in the synthesis of mono- and diprenylated indolines.{39398,39399} It has antibacterial activity and inhibits growth of 41 out of 49 strains of multidrug resistant A. baumannii (MICs = 12.5-25 µg/ml) as well as B. subtilis, M. luteus, S. aureus, S. cerevisiae, A. niger, and C. albicans (MICs = 12.5-50 µg/ml).{39400} Prenylated forms of cyclo(L-Trp-L-Trp) are cytotoxic against human leukemia and ovarian cell lines.{39401}  

 

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SKU: 23494 - 250 mg Category:

Description

A cyclic dipeptide; used as a substrate for indole prenyltransferases in the synthesis of mono- and diprenylated indolines; inhibits growth of 41 out of 49 strains of multidrug resistant A. baumannii (MICs = 12.5-25 µg/ml) as well as B. subtilis, M. luteus, S. aureus, S. cerevisiae, A. niger, and C. albicans (MICs = 12.5-50 µg/ml)

Formal name: 3S,6S-bis(1H-indol-3-ylmethyl)-2,5-piperazinedione

Synonyms:  Cyclic dioxopiperazine-L-tryptophan-L-tryptophan

Molecular weight: 372.4

CAS: 20829-55-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Lipid Biochemistry|Prenol Lipids

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