An antioxidant; exhibits hydroxyl radical scavenging activity in vitro; reduces occurrence of chronic cerebral vasospasms in a canine model of subarachnoid hemorrhage at intravenous doses ranging from 1-3 mg/kg per min; reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver in a canine model of warm hepatic ischemia and reperfusion injury; decreases the plasma levels of Il-6 and Tnf-α and the urinary levels of 8-oxo-2'-deoxyguanosine in a mouse model of radiation-induced injury

Nicaraven – 25 mg

Brand:
Cayman
CAS:
79455-30-4
Storage:
-20
UN-No:
Non-Hazardous - /

Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro.{36261} Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver.{36262} Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2′-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury.{36263}  

 

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SKU: 23482 - 25 mg Category:

Description

An antioxidant; exhibits hydroxyl radical scavenging activity in vitro; reduces occurrence of chronic cerebral vasospasms in a canine model of subarachnoid hemorrhage at intravenous doses ranging from 1-3 mg/kg per min; reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver in a canine model of warm hepatic ischemia and reperfusion injury; decreases the plasma levels of Il-6 and Tnf-α and the urinary levels of 8-oxo-2′-deoxyguanosine in a mouse model of radiation-induced injury

Formal name: N,N’-(1-methyl-1,2-ethanediyl)bis-3-pyridinecarboxamide

Synonyms: 

Molecular weight: 284.3

CAS: 79455-30-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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