An IL-5 receptor antagonist (IC50s = 1 and 0.57 µM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells

YM-90709 – 25 mg

Brand:
Cayman
CAS:
163769-88-8
Storage:
-20
UN-No:
Non-Hazardous - /

YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC50 values of 1 and 0.57 µM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay.{40323} It inhibits IL-5-induced eosinophil survival (IC50 = 0.45 µM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.{40324,40325}  

 

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SKU: 23448 - 25 mg Category:

Description

An IL-5 receptor antagonist (IC50s = 1 and 0.57 µM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively; inhibits IL-5-induced eosinophil survival (IC50 = 0.45 µM) and JAK2 phosphorylation in vitro; inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the BALF of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice

Formal name: 5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-benz[7,8]indolizino[2,3-b]quinoxaline

Synonyms: 

Molecular weight: 359.4

CAS: 163769-88-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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