Description
A MALT1 inhibitor (IC50 = 5.84 μM in a fluorescence assay); inhibits the growth of MALT1-dependent ABC-DLBCL cell lines (GI50s = 0.2, 0.5, 0.4, and 0.4 μM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, respectively); inhibits cleavage of the MALT1 target protein CYLD in a dose-dependent manner in HBL-1 cells; reduces tumor size in TMD8 and HBL-1 mouse xenograft models when administered at a dose of 25 mg/kg, i.v.
Formal name: 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenyl]-acetamide
Synonyms:
Molecular weight: 455.7
CAS: 1047953-91-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer
