A MALT1 inhibitor (IC50 = 5.84 μM in a fluorescence assay); inhibits the growth of MALT1-dependent ABC-DLBCL cell lines (GI50s = 0.2

MI 2 – 1 mg

Brand:
Cayman
CAS:
1047953-91-2
Storage:
-20
UN-No:
Non-Hazardous - /

MI 2 is an inhibitor of the paracaspase MALT1 with an IC50 value of 5.84 μM in a fluorescence assay.{36194} It inhibits the growth of MALT1-dependent activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines (GI50s = 0.2, 0.5, 0.4, and 0.4 μM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, respectively). MI 2 inhibits cleavage of the MALT1 target protein CYLD in a dose-dependent manner in HBL-1 cells but does not inhibit caspase-3, caspase-8, and caspase-9, which are structurally similar to MALT1. MI 2 (25 mg/kg, i.v.) reduces tumor size in TMD8 and HBL-1 mouse xenograft models.  

 

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Description

A MALT1 inhibitor (IC50 = 5.84 μM in a fluorescence assay); inhibits the growth of MALT1-dependent ABC-DLBCL cell lines (GI50s = 0.2, 0.5, 0.4, and 0.4 μM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, respectively); inhibits cleavage of the MALT1 target protein CYLD in a dose-dependent manner in HBL-1 cells; reduces tumor size in TMD8 and HBL-1 mouse xenograft models when administered at a dose of 25 mg/kg, i.v.

Formal name: 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenyl]-acetamide

Synonyms: 

Molecular weight: 455.7

CAS: 1047953-91-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer

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