A β-adrenergic receptor antagonist; antagonizes tachycardia induced by the β-AR agonist isoproterenol in dogs and anesthetized cats; cardioselective

Acebutolol (hydrochloride) – 10 g

Brand:
Cayman
CAS:
34381-68-5
Storage:
-20
UN-No:
Non-Hazardous - /

Acebutolol is an antagonist of β-adrenergic receptors (β-ARs).{39375} In dogs and anesthetized cats, acebutolol antagonizes tachycardia induced by the β-AR agonist isoproterenol (Item No. 15592). It is cardioselective, antagonizing tachycardia, diastolic hypotension, and bronchodilation with ED50 values of 0.09, 0.9, and 10.2 mg/kg, respectively. It has antiarrhythmic effects, restoring normal sinus rhythm in an ouabain-induced canine model of cardiac arrhythmia.{39376} Formulations containing acebutolol have been used to treat cardiac arrhythmias.{39377}  

 

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Description

A β-adrenergic receptor antagonist; antagonizes tachycardia induced by the β-AR agonist isoproterenol in dogs and anesthetized cats; cardioselective, antagonizing tachycardia, diastolic hypotension, and bronchodilation (ED50s = 0.09, 0.9, and 10.2 mg/kg, respectively); restores normal sinus rhythm in an ouabain-induced canine model of cardiac arrhythmia,

Formal name: N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-butanamide, monohydrochloride

Synonyms: 

Molecular weight: 372.9

CAS: 34381-68-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension||Research Area|Cardiovascular System|Heart|Arrhythmia

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