An antiviral agent; inhibits influenza A

T-705 – 10 mg

Brand:
Cayman
CAS:
259793-96-9
Storage:
-20
UN-No:
Non-Hazardous - /

T-705 is an antiviral agent that inhibits influenza A, B, and C (IC50s = 0.013-0.48 µg/ml) without inducing cytotoxicity up to 1,000 µg/ml.{38359} It inhibits a neuraminidase-resistant influenza strain (GS4071-resistant; IC50 = 0.095 µg/ml) and RNA viruses (IC50s = 4.8-41 µg/ml) but not DNA viruses at concentrations greater than 100 µg/ml. It is active against a variety of viruses, including bunyavirus, arenavirus, and West Nile virus in vitro and in vivo in mice.{38361} T-705 undergoes phosphoribosylation to form T-705-RTP, which inhibits RNA-dependent RNA polymerase (RdRp) in RNA viruses.{38360} In mice infected with influenza virus, T-705 (200 mg/kg once daily) decreases the rate of mortality and reduces the lung virus yield in a dose-dependent manner at doses ranging from 50-200 mg/kg per day.  

 

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SKU: 23384 - 10 mg Category:

Description

An antiviral agent; inhibits influenza A, B, and C (IC50s = 0.013-0.48 µg/ml); inhibits a GS4071-resistant influenza strain (IC50 = 0.095 µg/ml) and RNA viruses (IC50s = 4.8-41 µg/ml); not active against DNA viruses; undergoes phosphoribosylation to form T-705-RTP, the active form; decreases the rate of mortality in influenza-infected mice when used at a dose of 200 mg/kg once daily; reduces the lung virus yield in a dose-dependent manner at doses ranging from 50-200 mg/kg per day in influenza-infected mice,

Formal name: 6-fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide

Synonyms:  Favilavir|Favipiravir

Molecular weight: 157.1

CAS: 259793-96-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Infectious Disease|Viral Diseases|West Nile Virus

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