A 5-HT3 receptor antagonist (Ki = 995 nM and IC50 = 308 nM in rat cortical membranes); D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes); oral administration inhibits cisplatin-induced emesis in ferrets and apomorphine-induced emesis in dogs (ED50s = 6.170 and 0.45 mg/kg

Metoclopramide (hydrochloride) – 100 g

Brand:
Cayman
CAS:
7232-21-5
Storage:
-20
UN-No:
Non-Hazardous - /

Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes.{36215,36216} It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes).{36216} Oral administration of metoclopramide inhibits emesis induced by cisplatin (Item No. 13119) and apomorphine (Item No. 16094) in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively.{36215,36216} Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively).{36217} Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.{36218,36219}  

 

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SKU: 23360 - 100 g Category:

Description

A 5-HT3 receptor antagonist (Ki = 995 nM and IC50 = 308 nM in rat cortical membranes); D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes); oral administration inhibits cisplatin-induced emesis in ferrets and apomorphine-induced emesis in dogs (ED50s = 6.170 and 0.45 mg/kg, respectively); reversibly inhibits human AChE isolated from caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively)

Formal name: 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide, monohydrochloride

Synonyms:  NSC 354467

Molecular weight: 336.3

CAS: 7232-21-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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