A synthetic progestogen; binds to the progesterone

Drospirenone – 250 mg

Brand:
Cayman
CAS:
67392-87-4
Storage:
-20
UN-No:
Non-Hazardous - /

Drospirenone is a synthetic progestogen that binds to the progesterone, mineralocorticoid, and androgen receptors with binding affinities of 20, 230, and 65% relative to R5020, aldosterone (Item No. 15273), and R1881, respectively.{41140} In vivo, drospirenone inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day) when administered orally or subcutaneously.{41141} Drospirenone (0.5 mg/animal) administered six times per day maintains pregnancy in ovariectomized pregnant rats. It reduces serum testosterone (Item Nos. 15645 | ISO60154) and luteinizing hormone in cynomolgus monkeys in a dose-dependent manner. Drospirenone (10 mg/animal per day) also inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats. Formulations containing drospirenone have been used as oral contraceptives.{41142}  

 

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SKU: 23347 - 250 mg Category:

Description

A synthetic progestogen; binds to the progesterone, mineralocorticoid, and androgen receptors with binding affinities of 20, 230, and 65% relative to R5020, aldosterone, and R1881, respectively; inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day); maintains pregnancy in ovariectomized pregnant rats; reduces serum testosterone and luteinizing hormone in cynomolgus monkeys; inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats

Formal name: 1,3′,4′,6R,7R,8R,9S,10R,11,12,13S,14S,15S,16S,20,21-hexadecahydro-10,13-dimethyl-spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2’S(5’H)-furan]-3,5′(2H)-dione

Synonyms:  1,2-dihydro Spirorenone|ZK 30595

Molecular weight: 366.5

CAS: 67392-87-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Endocrinology & Metabolism|Reproductive Biology

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