An inhibitor of p18 that promotes expansion of murine and human HSCs; promotes HSC expansion in a single-cell in vitro culture assay using isolated murine bone marrow cells (ED50 = 5.21 nM); increases HSC proliferation without affecting differentiation

NSC 23005 (sodium salt) – 5 mg

Brand:
Cayman
CAS:
1796596-46-7
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 23005 is a small molecule inhibitor of p18, as determined by an in silico screen.{38496} It promotes expansion of murine and human hematopoietic stem cells (HSCs) with an ED50 value of 5.21 nM in a single-cell in vitro culture assay using isolated murine bone marrow cells. NSC 23005 increases the number of long-term HSCs following treatment with a CDK2 inhibitor but not a CDK4/6 inhibitor, indicating that it mediates its effects by blocking p18 inhibition of CDK4/6. It increases HSC proliferation without affecting differentiation, inducing cytotoxicity, or affecting leukemia cell proliferation.  

 

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SKU: 23327 - 5 mg Category:

Description

An inhibitor of p18 that promotes expansion of murine and human HSCs; promotes HSC expansion in a single-cell in vitro culture assay using isolated murine bone marrow cells (ED50 = 5.21 nM); increases HSC proliferation without affecting differentiation, inducing cytotoxicity, or affecting leukemia cell proliferation

Formal name: 4-[(cyclohexylamino)sulfonyl]-benzoic acid, monosodium salt

Synonyms: 

Molecular weight: 305.3

CAS: 1796596-46-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Stem Cell Research|Proliferation

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