A potent and selective ERβ agonist (IC50s = 2 and 187 nM for human full-length ERβ and ERα

WAY-200070 – 5 mg

Brand:
Cayman
CAS:
440122-66-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

WAY-200070 is a potent and selective agonist of estrogen receptor β (ERβ; IC50s = 2 and 187 nM for human full-length ERβ and ERα, respectively).{39360} WAY-200070 (30 mg/kg, s.c. in mice) induces nuclear translocation of ERβ and increases c-fos activation and dopamine levels in the striatum four hours after administration.{39359} At the same dose, it decreases depressive-like behavior in the tail suspension test. It has anxiolytic effects in mice using the four-plate and stress-induced hyperthermia tests and in zebrafish larvae using a light-dark choice behavior test.{39359,39358} In addition, WAY-200070 improves glucose and insulin sensitivity in mouse models of diabetes.{39357}  

 

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SKU: 23323 - 5 mg Category:

Description

A potent and selective ERβ agonist (IC50s = 2 and 187 nM for human full-length ERβ and ERα, respectively); induces nuclear translocation of ERβ and increases c-fos activation and dopamine levels in the striatum four hours after administration; decreases depressive-like behaviors and has anxiolytic effects in mice; improves glucose and insulin sensitivity in mouse models of diabetes,

Formal name: 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol

Synonyms:  WAY-00005

Molecular weight: 306.1

CAS: 440122-66-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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