A selective inhibitor of RIPK3; >1

GSK872 – 10 mg

Brand:
Cayman
CAS:
1346546-69-7
Storage:
-20
UN-No:
Non-Hazardous - /

GSK872 is an inhibitor of receptor-interacting protein kinase 3 (RIPK3).{37147} It is selective for RIPK3, having >1,000-fold selectivity over 300 kinases in a fluorescence polarization assay at a concentration of 1 μM. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. It also inhibits necrosis induced by toll-like receptor 3 (TLR3).  

 

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SKU: 23300 - 10 mg Category:

Description

A selective inhibitor of RIPK3; >1,000-fold selectivity over 300 kinases in a fluorescence polarization assay at a concentration of 1 μM; inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts; inhibits necrosis induced by TLR3

Formal name: N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine

Synonyms: 

Molecular weight: 383.5

CAS: 1346546-69-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Death|Necrosis||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Viral Diseases

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