A neurotoxic non-proteinogenic amino acid; cytotoxic to mouse primary cortical neurons at 3 mM; stimulates release of glutamate and induces oxidative stress in the same cells at 3 mM; enhances amyloid-β (25-35)-induced neuronal cell death in mouse primary cortical neurons at 0.1 mM; induces wet-dog shakes

β-Methylamino-L-Alanine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
16012-55-8
Storage:
-20
UN-No:
Non-Hazardous - /

β-Methylamino-L-alanine (BMAA) is a neurotoxic non-proteinogenic amino acid that has been found in cyanobacteria.{59025,59026} It is cytotoxic to mouse primary cortical neurons when used at a concentration of 3 mM in the presence of bicarbonate, an effect that can be blocked by the NMDA receptor antagonist MK-801 or the mGluR5 receptor antagonist MPEP (Item No. 14536).{59027} BMAA (3 mM) stimulates release of glutamate and induces oxidative stress in the same cells.{59028} It also enhances neuronal cell death induced by amyloid-β (25-35) in mouse primary cortical neurons when used at a concentration of 0.1 mM.{59027} Intracerebroventricular administration of BMAA (500 µg/animal) induces wet-dog shakes, rigidity, and clonic convulsions in rats.{59029} It induces parkinsonism in cynomolgus monkeys.{59030} BMAA has been found in commercial seafood.{59031}  

 

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SKU: 23287 - 5 mg Category:

Description

A neurotoxic non-proteinogenic amino acid; cytotoxic to mouse primary cortical neurons at 3 mM; stimulates release of glutamate and induces oxidative stress in the same cells at 3 mM; enhances amyloid-β (25-35)-induced neuronal cell death in mouse primary cortical neurons at 0.1 mM; induces wet-dog shakes, rigidity, and clonic convulsions in rats at 500 µg/animal; induces parkinsonism in cynomolgus monkeys; has been found in commercial seafood

Formal name: 3-(methylamino)-L-alanine, monohydrochloride

Synonyms:  BMAA|L-BMAA

Molecular weight: 154.6

CAS: 16012-55-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Toxins||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Seizure Disorders||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity

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