A neuropeptide and δ- and µ-opioid receptor agonist (Kis = 4.0 and 3.4 nM

Leu-Enkephalin – 10 mg

Brand:
Cayman
CAS:
58822-25-6
Storage:
-20
UN-No:
Non-Hazardous - /

Leu-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ- and µ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively).{42332,25533} It is selective for δ- and µ- over κ-opioid receptors (Ki = >1,000 nM).{25533} Leu-Enkephalin is a cleavage product of proenkephalin, which is found primarily in the adrenal medulla and the CNS.{42333} It is found in the brain, the brainstem, and the spinal cord as well as in the peripheral nervous system. Leu-Enkephalin (1 mg/kg) decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension.{43325} It also increases the tail-flick threshold and latency to tail flick in the tail-pressure test and tail-flick test, respectively, in mice.{43324}  

 

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SKU: 23283 - 10 mg Category:

Description

A neuropeptide and δ- and µ-opioid receptor agonist (Kis = 4.0 and 3.4 nM, respectively); selective for δ- and µ- over κ-opioid receptors (Ki = >1,000 nM); decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension at 1 mg/kg; increases the tail-flick threshold and latency to tail flick in the tail-pressure test and tail-flick test, respectively

Formal name: L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Synonyms:  [Leu5]enkephalin|Leucine enkephalin|NSC 350588|Tyr-Gly-Gly-Phe-Leu-OH

Molecular weight: 555.6

CAS: 58822-25-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Pain Research

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