A potent inhibitor of p38α MAP kinase (IC50 = 7 nM for human recombinant p38α); inhibits LPS-induced TNF-α production in murine peritoneal macrophages and reduces phosphorylation of MK2 in RAW 264.7 cells (IC50s = 5.2 and 34.3 nM

LY2228820 (mesylate) – 25 mg

Brand:
Cayman
CAS:
862507-23-1
Storage:
-20
UN-No:
Non-Hazardous - /

LY2228820 is a potent inhibitor of p38α MAP kinase (IC50 = 7 nM for human recombinant p38α).{39389} It inhibits LPS-induced TNF-α production in murine peritoneal macrophages and reduces phosphorylation of MAPKAPK-2 (MK2) in RAW 264.7 cells (IC50s = 5.2 and 34.3 nM, respectively). LY2228820 inhibits TNF-α production in LPS-treated mice and reduces paw swelling and cartilage destruction in a rat model of chronic inflammation with threshold minimum 50% doses (TMED50) values of <1, 1.5, and 1.5 mg/kg, respectively.  

 

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SKU: 23259 - 25 mg Category:

Description

A potent inhibitor of p38α MAP kinase (IC50 = 7 nM for human recombinant p38α); inhibits LPS-induced TNF-α production in murine peritoneal macrophages and reduces phosphorylation of MK2 in RAW 264.7 cells (IC50s = 5.2 and 34.3 nM, respectively); inhibits TNF-α production in LPS-treated mice and reduces paw swelling and cartilage destruction in a rat model of chronic inflammation (TMED50s = <1, 1.5, and 1.5 mg/kg, respectively)

Formal name: 5-[2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine, dimethanesulfonate

Synonyms:  LSN2322600

Molecular weight: 612.7

CAS: 862507-23-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Innate Immunity

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