A potent cathepsin L inhibitor (IC50 = 0.85 nM); selective for cathepsin L over calpain II and cathepsin B (IC50s = 184

Cathepsin L Inhibitor – 1 mg

Brand:
Cayman
CAS:
167498-29-5
Storage:
-20
UN-No:
Non-Hazardous - /

Cathepsin L inhibitor is a potent inhibitor of cathepsin L (IC50 = 0.85 nM).{41143} It is selective for cathepsin L over calpain II and cathepsin B (IC50s = 184, and 85.1 nM, respectively). It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells.{41145} Cathepsin L inhibitor completely suppresses osteoclastic pit formation on femur slices isolated from bovine cortical bone at a concentration of 1 μg/ml.{41143},{41144} In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner.  

 

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SKU: 23249 - 1 mg Category:

Description

A potent cathepsin L inhibitor (IC50 = 0.85 nM); selective for cathepsin L over calpain II and cathepsin B (IC50s = 184, and 85.1 nM, respectively); trypanocidal against T. brucei (ED50 = 45 nM); completely suppresses osteoclastic pit formation on femur slices isolated from bovine cortical bone at a concentration of 1 μg/ml; inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner

Formal name: N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester

Synonyms:  SB 412515

Molecular weight: 446.5

CAS: 167498-29-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness

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