A tyrphostin EGFR inhibitor (IC50 = 0.7 μM); selectively inhibits EFGR over ErbB2 (IC50 = 35 μM); inhibits EGF-dependent growth of HER 14 cells (IC50 = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis from 1-50 μM; inhibits Mo-MuLV reverse transcriptase activity (IC50 = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC50 = 210 μM)

AG-555 – 5 mg

Brand:
Cayman
CAS:
133550-34-2
Storage:
-20
UN-No:
Non-Hazardous - /

AG-555 is a tyrphostin inhibitor of the EGF receptor (EGFR; IC50 = 0.7 μM).{45071} It selectively inhibits EFGR over ErbB2 (IC50 = 35 μM). AG-555 inhibits EGF-dependent growth of HER 14 cells (IC50 = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis when used at concentrations ranging from 1 to 50 μM.{45071,45072} It also inhibits Moloney murine leukemia virus (Mo-MuLV) reverse transcriptase activity (IC50 = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC50 = 210 μM).{45073}  

 

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SKU: 23247 - 5 mg Category:

Description

A tyrphostin EGFR inhibitor (IC50 = 0.7 μM); selectively inhibits EFGR over ErbB2 (IC50 = 35 μM); inhibits EGF-dependent growth of HER 14 cells (IC50 = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis from 1-50 μM; inhibits Mo-MuLV reverse transcriptase activity (IC50 = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC50 = 210 μM)

Formal name: (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide

Synonyms:  Tyrphostin AG-555|Tyrphostin B46

Molecular weight: 322.4

CAS: 133550-34-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Viral Diseases

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