A class IIa HDAC inhibitor (Kis = 59

TMP-195 – 25 mg

Brand:
Cayman
CAS:
1314891-22-9
Storage:
-20
UN-No:
Non-Hazardous - /

TMP-195 is an inhibitor of class IIa histone deacetylases (HDACs; Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively).{28861} It is selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 μM for HDAC1-3, 6, 9, and 10-11). TMP-195 blocks accumulation of chemoattractant chemokine ligand 2 (CCL2) in the supernatant of monocytes stimulated with macrophage colony-stimulating factor (CSF-1). It increases secretion of CCL1 by monocytes stimulated with CSF-1 and granulocyte/monocyte colony-stimulating factor (GM-CSF). In vivo, TMP-195 reduces tumor burden and the number of pulmonary metastases in a macrophage-dependent autochthonous mouse model of breast cancer.{42136}  

 

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SKU: 23242 - 25 mg Category:

Description

A class IIa HDAC inhibitor (Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively); selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 μM for HDAC1-3, 6, 9, and 10-11); blocks accumulation of CCL2 in the supernatant of CSF-1-stimulated monocytes; increases secretion of CCL1 by CSF-1 and GM-CSF-stimulated monocytes; reduces tumor burden and the number of pulmonary metastases in a macrophage-dependent autochthonous mouse model of breast cancer,

Formal name: N-[2-methyl-2-(2-phenyl-4-oxazolyl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-benzamide

Synonyms: 

Molecular weight: 456.4

CAS: 1314891-22-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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