A natural prenylated chalcone with diverse biological activities; has antiproliferative

Isoxanthohumol – 5 mg

Brand:
Cayman
CAS:
521-48-2
Storage:
-20
UN-No:
Non-Hazardous - /

Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties.{40233} In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC50s = 22.15 and 22.9 µM in an MTT assay), slows cell division, and induces apoptosis.{40231} Isoxanthohumol reversibly inhibits Kv1.3 channels with an EC50 value of 7.8 µM in human Jurkat T cells using patch clamp electrophysiology.{40230} It has strong deterrent properties against the peach potato aphid.{40234} It has also been used as a marker of beer consumption.{40232} Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin (Item No. 17462), a potent phytoestrogen.{40232}  

 

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Description

A natural prenylated chalcone with diverse biological activities; has antiproliferative, anti-inflammatory, and antiviral properties; inhibits proliferation (IC50s = 22.15 and 22.9 µM in an MTT assay) of B16 and A375 melanoma cells; inhibits Kv1.3 channels (EC50 = 7.8 µM); acts as a strong deterrent against the peach potato aphid; has been used as a marker of beer consumption; metabolized to 8-prenylnaringenin, a potent phytoestrogen

Formal name: 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

Synonyms:  IX|IXN

Molecular weight: 354.4

CAS: 521-48-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Chalcones||Product Type|Biochemicals|Pesticides||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases

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