An inhibitor of heme production; inhibits ferrochelatase; induces Mallory-Denk body formation in mouse liver; reduces IL-12A methylation in mouse liver

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate – 50 g

Brand:
Cayman
CAS:
632-93-9
Storage:
-20
UN-No:
Non-Hazardous - /

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B.{40300} Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.{40301,40299}  

 

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SKU: 23230 - 50 g Category:

Description

An inhibitor of heme production; inhibits ferrochelatase; induces Mallory-Denk body formation in mouse liver; reduces IL-12A methylation in mouse liver

Formal name: 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester

Synonyms:  3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine|DDC|NSC 49528|NSC 8910

Molecular weight: 267.3

CAS: 632-93-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH

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