A monoterpene with anti-inflammatory activity; stimulates proliferation of lymphocytes derived from allergic patients in vitro at 6.2 and 62 µg/ml; decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at 0.1-10 µM; decreases serum IgE levels and skin protein levels of inflammatory cytokines including IFN-γ

(R)-(+)-Pulegone – 25 g

Brand:
Cayman
CAS:
89-82-7
Storage:
-20
UN-No:
Non-Hazardous - /

(R)-(+)-Pulegone is a monoterpene that has been found in a variety of plants, including Labiatae species and M. verticillata, and has anti-inflammatory activity.{37731} It stimulates proliferation of lymphocytes derived from allergic patients in vitro when used at concentrations of 6.2 and 62 µg/ml and reduces the level of IL-13 in supernatant from lymphocyte cultures when used at a concentration of 62 µg/ml.{37732} (R)-(+)-Pulegone decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at doses ranging from 0.1 to 10 µM. It also decreases serum IgE levels and skin protein levels of nerve growth factor, IFN-γ, IL-6, IL-1β, TNF-α, NF-κB, phosphorylated ERK1/2, and phosphorylated JNK.  

 

Available on backorder

Add to quotes
SKU: 23163 - 25 g Category:

Description

A monoterpene with anti-inflammatory activity; stimulates proliferation of lymphocytes derived from allergic patients in vitro at 6.2 and 62 µg/ml; decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at 0.1-10 µM; decreases serum IgE levels and skin protein levels of inflammatory cytokines including IFN-γ, IL-6, IL-1β, TNF-α, and NF-κB in skin

Formal name: 5R-methyl-2-(1-methylethylidene)-cyclohexanone

Synonyms:  D-Pulegone|NSC 15334

Molecular weight: 152.2

CAS: 89-82-7

Purity: ≥95%

Formulation: A neat oil

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Immunology & Inflammation|Adaptive Immunity

Related products

  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 25 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 25 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 100 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 100 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page