A monoterpene with anti-inflammatory activity; stimulates proliferation of lymphocytes derived from allergic patients in vitro at 6.2 and 62 µg/ml; decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at 0.1-10 µM; decreases serum IgE levels and skin protein levels of inflammatory cytokines including IFN-γ

(R)-(+)-Pulegone – 10 g

Brand:
Cayman
CAS:
89-82-7
Storage:
-20
UN-No:
Non-Hazardous - /

(R)-(+)-Pulegone is a monoterpene that has been found in a variety of plants, including Labiatae species and M. verticillata, and has anti-inflammatory activity.{37731} It stimulates proliferation of lymphocytes derived from allergic patients in vitro when used at concentrations of 6.2 and 62 µg/ml and reduces the level of IL-13 in supernatant from lymphocyte cultures when used at a concentration of 62 µg/ml.{37732} (R)-(+)-Pulegone decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at doses ranging from 0.1 to 10 µM. It also decreases serum IgE levels and skin protein levels of nerve growth factor, IFN-γ, IL-6, IL-1β, TNF-α, NF-κB, phosphorylated ERK1/2, and phosphorylated JNK.  

 

Available on backorder

Add to quotes
SKU: 23163 - 10 g Category:

Description

A monoterpene with anti-inflammatory activity; stimulates proliferation of lymphocytes derived from allergic patients in vitro at 6.2 and 62 µg/ml; decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at 0.1-10 µM; decreases serum IgE levels and skin protein levels of inflammatory cytokines including IFN-γ, IL-6, IL-1β, TNF-α, and NF-κB in skin

Formal name: 5R-methyl-2-(1-methylethylidene)-cyclohexanone

Synonyms:  D-Pulegone|NSC 15334

Molecular weight: 152.2

CAS: 89-82-7

Purity: ≥95%

Formulation: A neat oil

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Immunology & Inflammation|Adaptive Immunity

Related products

  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 25 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 25 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 100 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 10 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 500 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page