An antagonist of CCR9 (IC50 = 5.4 nM); selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 µM for all); inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM

Vercirnon – 1 mg

Brand:
Cayman
CAS:
698394-73-9
Storage:
-20
UN-No:
Non-Hazardous - /

Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells.{47155} It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 µM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents G protein coupling.{47156}  

 

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SKU: 23131 - 1 mg Category:

Description

An antagonist of CCR9 (IC50 = 5.4 nM); selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 µM for all); inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively)

Formal name: N-[4-chloro-2-[(1-oxido-4-pyridinyl)carbonyl]phenyl]-4-(1,1-dimethylethyl)-benzenesulfonamide

Synonyms:  CCX282-B|GSK1605786

Molecular weight: 444.9

CAS: 698394-73-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Adaptive Immunity

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