A vitamin D3 analog with diverse biological activities; increases death of androgen-stimulated BPH cells via induction of apoptosis in a dose-dependent manner; completely inhibits androgen-stimulated prostate overgrowth in a rat model of benign prostatic hyperplasia; reduces expression of IL-13 and MMCP1 and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis; reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis

BXL-628 – 5 mg

Brand:
Cayman
CAS:
199798-84-0
Storage:
-20
UN-No:
Non-Hazardous - /

BXL-628 is an analog of vitamin D3 (Item No. 11792) that has diverse biological activities.{40147,40148,40149} It increases death of androgen-stimulated human benign prostatic hyperplasia (BPH) cells via induction of apoptosis in a dose-dependent manner.{40147} In vivo, BXL-628 completely inhibits androgen-stimulated prostate overgrowth in a rat model of BPH. It reduces expression of IL-13 and IgE/mast cell-derived protease 1 (MMCP1) and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis.{40148} BXL-628 also reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis.{40149} Formulations containing BXL-628 are under clinical investigation for the treatment of BPH.  

 

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SKU: 23129 - 5 mg Category:

Description

A vitamin D3 analog with diverse biological activities; increases death of androgen-stimulated BPH cells via induction of apoptosis in a dose-dependent manner; completely inhibits androgen-stimulated prostate overgrowth in a rat model of benign prostatic hyperplasia; reduces expression of IL-13 and MMCP1 and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis; reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis

Formal name: (1R,3Z,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(1S,3E)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylene-cyclohexanol

Synonyms:  Elocalcitol|Ro 26-9228

Molecular weight: 442.7

CAS: 199798-84-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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