A nucleoside analog; converted intracellularly to 3-deazauridine triphosphate

3-Deazauridine – 25 mg

Brand:
Cayman
CAS:
23205-42-7
Storage:
-20
UN-No:
Non-Hazardous - /

3-Deazauridine is a nucleoside analog.{41307} It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.{41306} It also enhances the incorporation of decitabine (Item No. 11166) into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.{41308}  

 

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SKU: 23125 - 25 mg Category:

Description

A nucleoside analog; converted intracellularly to 3-deazauridine triphosphate, which inhibits the biosynthesis of CTP; inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM; dose-dependently reduces mortality in a mouse model of leukemia; enhances the incorporation of decitabine into DNA in leukemia cells when used at a concentration of 20 µM; reduces mortality when used at a dose of 100 or 150 mg/kg and combined with decitabine in a mouse model of leukemia

Formal name: 4-hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone

Synonyms:  NSC 126849

Molecular weight: 243.2

CAS: 23205-42-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer

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