Description
A nucleoside analog; converted intracellularly to 3-deazauridine triphosphate, which inhibits the biosynthesis of CTP; inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM; dose-dependently reduces mortality in a mouse model of leukemia; enhances the incorporation of decitabine into DNA in leukemia cells when used at a concentration of 20 µM; reduces mortality when used at a dose of 100 or 150 mg/kg and combined with decitabine in a mouse model of leukemia
Formal name: 4-hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone
Synonyms: NSC 126849
Molecular weight: 243.2
CAS: 23205-42-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer
