A broad spectrum antifungal agent; active against various fungi

Luliconazole – 1 g

Brand:
Cayman
CAS:
187164-19-8
Storage:
-20
UN-No:
Non-Hazardous - /

Luliconazole is a broad spectrum imidazole that is active against various fungi, including Tinea, Candida, Trichophyton, Aspergillus, and Epidermophyton.{40272,40274} It has MIC values of 2.5-20, 0.63-2.5, 31-250, and ≤0.31-0.63 ng/ml for T. mentagrophytes, T. rubrum, C. albicans, and A. fumigatus, respectively, in broth dilution assays. In vitro, luliconazole has a geometric mean MIC value of 2.35 ng/ml against A. terreus, a fungal species responsible for life-threatening invasive aspergillosis in immunocompromised and high-risk patients.{40273} It prevents mortality in rats with systemic A. fumigatus infections and in mice with systemic C. albicans infections.{40274} It is effective in eliminating tinea pedis in a guinea pig model when used topically at a concentration of 1% once per day for seven days.{40272} Topical formulations containing luliconazole have been used in the treatment of fungal infections.  

 

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SKU: 23120 - 1 g Category:

Description

A broad spectrum antifungal agent; active against various fungi, including Tinea, Candida, Trichophyton, Aspergillus, and Epidermophyton; has MIC values of 2.5-20, 0.63-2.5, 31-250, and ≤0.31-0.63 ng/ml for T. mentagrophytes, T. rubrum, C. albicans, and A. fumigatus, respectively, in broth dilution assays; has an in vitro geometric mean MIC value of 2.35 ng/ml against A. terreus; prevents mortality in mice and rats with systemic fungal infections; effective in eliminating tinea pedis in a guinea pig model when used at a topical concentration of 1%

Formal name: αE-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile

Synonyms:  NND-502

Molecular weight: 354.3

CAS: 187164-19-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Imidazoles||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Fungal Diseases|Ringworm

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