An active metabolite of ebastine; acts as an antagonist at histamine H1 receptors (IC50 = 45 nM); decreases production of RANTES/CCL5 and MCP-1/CCL2 in HNECs isolated from patients with nasal allergies

Carebastine – 5 mg

Brand:
Cayman
CAS:
90729-42-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Carebastine is an active metabolite of ebastine (Item No. 15372).{24985,34756} Ebastine undergoes extensive first-pass metabolism by the hepatic cytochrome P450 (CYP) isomer CYP3A4 into carebastine, which acts as an antagonist at histamine H1 receptors (IC50 = 45 nM).{34756,24986} Carebastine decreases production of RANTES/CCL5 and monocyte chemoattractant protein 1 (MCP-1/CCL2) in human nasal epithelial cells (HNECs) isolated from patients with nasal allergies.{41052}  

 

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SKU: 23076 - 5 mg Category:

Description

An active metabolite of ebastine; acts as an antagonist at histamine H1 receptors (IC50 = 45 nM); decreases production of RANTES/CCL5 and MCP-1/CCL2 in HNECs isolated from patients with nasal allergies

Formal name: 4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl-benzeneacetic acid

Synonyms: 

Molecular weight: 499.6

CAS: 90729-42-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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