A dual P2X3 and P2X2/3 receptor antagonist (IC50s = 10 and 79.4 nM

AF-353 – 10 mg

Brand:
Cayman
CAS:
865305-30-2
Storage:
-20
UN-No:
Non-Hazardous - /

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively).{47203,47204} It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all).{47204} It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.{47205}  

 

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SKU: 23034 - 10 mg Category:

Description

A dual P2X3 and P2X2/3 receptor antagonist (IC50s = 10 and 79.4 nM, respectively); selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all); inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively); decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats

Formal name: 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine

Synonyms:  Ro-4

Molecular weight: 400.2

CAS: 865305-30-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience

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