An oxazolidinone-type antibiotic; has activity against a panel of C. difficile strains (MICs = 0.125-0.5 μg/ml); inhibits toxin A and B formation in stationary-phase cultures and spore formation in late exponential cultures of the toxigenic C. difficile strain ATCC 9689; inhibits C. difficile protein synthesis (IC50s = 0.08-0.31 μg/ml); increases survival in a mouse model of CDAD at 1 and 10 mg/kg; increases survival in a hamster model of CDAD at >3 mg/kg

Cadazolid – 5 mg

Brand:
Cayman
CAS:
1025097-10-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cadazolid is an oxazolidinone-type antibiotic that has activity against a panel of C. difficile strains, including those resistant to fluoroquinolones and linezolid (Item No. 15012; MICs = 0.125-0.5 μg/ml).{43211} It inhibits toxin A and B formation in stationary-phase cultures and spore formation in late exponential cultures of the toxigenic C. difficile strain ATCC 9689. Cadazolid inhibits C. difficile protein synthesis (IC50s = 0.08-0.31 μg/ml) without affecting nucleic acid or cell wall synthesis (IC50s = 12-18.6 and >32 μg/ml, respectively).{43212} In vivo, cadazolid (1 and 10 mg/kg) increases survival in a mouse model of C. difficile-associated diarrhea (CDAD). It also confers 100% survival in a hamster model of CDAD when administered at doses greater than 3 mg/kg.{43211}  

 

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SKU: 23030 - 5 mg Category:

Description

An oxazolidinone-type antibiotic; has activity against a panel of C. difficile strains (MICs = 0.125-0.5 μg/ml); inhibits toxin A and B formation in stationary-phase cultures and spore formation in late exponential cultures of the toxigenic C. difficile strain ATCC 9689; inhibits C. difficile protein synthesis (IC50s = 0.08-0.31 μg/ml); increases survival in a mouse model of CDAD at 1 and 10 mg/kg; increases survival in a hamster model of CDAD at >3 mg/kg

Formal name: 1-cyclopropyl-6-fluoro-7-[4-[[2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]phenoxy]methyl]-4-hydroxy-1-piperidinyl]-1-4-dihydro-4-oxo-3-quinolinecarboxylic acid

Synonyms:  ACT-179811

Molecular weight: 585.6

CAS: 1025097-10-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Oxazolidinones||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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