Description
An FGFR4 inhibitor (IC50 = 1.9 nM); inhibits proliferation of Huh7 cells (IC50 = 12 nM) induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids at 45 mg/kg per day for four weeks; decreases serum cholesterol at 5-45 mg/kg per day
Formal name: N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide
Synonyms: Roblitinib
Molecular weight: 506.6
CAS: 1708971-55-4
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias
