A synthetic corticosteroid; a glucocorticoid receptor agonist (IC50 = 2.0 nM); increases transcriptional activity of the glucocorticoid receptor in HeLa cells (EC50 = 0.7 nM); dose-dependently inhibits VEGF secretion; decreases TNF-α-induced angiogenesis in a chick chorioallantoic membrane assay

Fluocinolone acetonide – 1 g

Brand:
Cayman
CAS:
67-73-2
Storage:
-20
UN-No:
Non-Hazardous - /

Fluocinolone acetonide is a synthetic fluorinated corticosteroid that acts as a glucocorticoid receptor agonist (IC50 = 2.0 nM in a radioligand binding assay).{39366} It increases transcriptional activity of the glucocorticoid receptor in HeLa cells (EC50 = 0.7 nM). It inhibits VEGF secretion in a dose-dependent manner and decreases TNF-α-induced angiogenesis in a chick chorioallantoic membrane assay.{39365} Formulations containing fluocinolone acetonide have been used for the treatment of various skin, eye, ear, and nose conditions to reduce inflammation.  

 

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SKU: 23027 - 1 g Category:

Description

A synthetic corticosteroid; a glucocorticoid receptor agonist (IC50 = 2.0 nM); increases transcriptional activity of the glucocorticoid receptor in HeLa cells (EC50 = 0.7 nM); dose-dependently inhibits VEGF secretion; decreases TNF-α-induced angiogenesis in a chick chorioallantoic membrane assay,

Formal name: 6α,9-difluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione

Synonyms:  NSC 92339

Molecular weight: 452.5

CAS: 67-73-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation

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