An eIF4E inhibitor; inhibits proliferation of JEKO-1 and Mino MCL

Briciclib – 1 mg

Brand:
Cayman
CAS:
865783-99-9
Storage:
-20
UN-No:
Non-Hazardous - /

Briciclib is a water soluble derivative of ON 013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).{39361} Briciclib inhibits proliferation of JEKO-1 and Mino mantle cell leukemia (MCL), MCF-7 and MDA-MB-231 breast, AGS gastric, and OE19, OE33, and LFO-1 esophageal cancer cell lines with GI50 values ranging from 9.8 to 12.2 nM. It reduces expression of cyclin D1 and c-Myc, markers of eIF4E activity, in breast and MCL cancer cell lines in a dose-dependent manner. Briciclib also induces expression of the pro-apoptotic proteins p53 and cleaved caspase-3.  

 

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SKU: 22989 - 1 mg Category:

Description

An eIF4E inhibitor; inhibits proliferation of JEKO-1 and Mino MCL, MCF-7 and MDA-MB-231 breast, AGS gastric, and OE19, OE33, and LFO-1 esophageal cancer cell lines (GI50s = 9.8-12.2 nM); reduces expression of cyclin D1 and c-Myc, markers of eIF4E activity, in breast and MCL cancer cell lines in a dose-dependent manner; induces expression of the pro-apoptotic proteins p53 and cleaved caspase-3,

Formal name: 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-phenol 1-(dihydrogen phosphate)

Synonyms:  ON-014185

Molecular weight: 474.4

CAS: 865783-99-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53

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