A selective AT2 receptor antagonist (IC50s = 39.5 and 408

EMA401 – 10 mg

Brand:
Cayman
CAS:
1316755-16-4
Storage:
-20
UN-No:
Non-Hazardous - /

EMA401 is an orally bioavailable and selective antagonist of the angiotensin II type 2 receptor (AT2; IC50s = 39.5 and 408,000 nM for rat recombinant AT2 and AT1, respectively).{47001} It inhibits capsaicin-induced calcium influx in cultured human dorsal root ganglion (hDRG) neurons (IC50 = 10 nM) and reduces neurite density and length in rat DRG neuronal cultures.{47002} EMA401 has analgesic effects in a rat model of neuropathic pain induced by chronic constriction injury.{47003}  

 

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SKU: 22988 - 10 mg Category:

Description

A selective AT2 receptor antagonist (IC50s = 39.5 and 408,000 nM for rat recombinant AT2 and AT1, respectively); inhibits capsaicin-induced calcium influx in cultured hDRG neurons (IC50 = 10 nM); reduces neurite density and length in rat DRG neuronal cultures; has analgesic effects in a rat model of neuropathic pain induced by chronic constriction injury

Formal name: (3S)-2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid

Synonyms: 

Molecular weight: 507.6

CAS: 1316755-16-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Pain Research

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