A competitive antagonist of nAChRs and non-depolarizing muscle relaxant; inhibits acetylcholine stimulation of human adult muscle nAChRs (IC50 = 10 nM); inhibits mouse nAChRs (IC50s = 54 and 115 nM for adult and embryonic receptors

Cisatracurium (besylate) – 50 mg

Brand:
Cayman
CAS:
96946-42-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Cisatracurium is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs) and non-depolarizing muscle relaxant.{43025,43024} It inhibits stimulation of human adult muscle nAChRs by acetylcholine (Item No. 23829) with an IC50 value of 10 nM.{43025} It also inhibits mouse nAChRs with IC50 values of 54 and 115 nM for adult and embryonic receptors, respectively.{43027} Cisatracurium increases apoptosis in HUVEC cells and decreases proliferation of HepG2 and HUVEC cells in vitro in a concentration-dependent manner.{43028,43029} It reduces the magnitude of electrically-evoked twitch tensions in isolated rat extensor digitorum longus and soleus sciatic nerve muscle preparations in a dose-dependent manner.{43024} Cisatracurium blocks electrically-evoked muscle twitches in anesthetized rabbits with an ED95 value of 0.04 mg/kg.{43026} Formulations containing cisatracurium have been used to facilitate intubation prior to surgery and as muscle relaxants.  

 

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Description

A competitive antagonist of nAChRs and non-depolarizing muscle relaxant; inhibits acetylcholine stimulation of human adult muscle nAChRs (IC50 = 10 nM); inhibits mouse nAChRs (IC50s = 54 and 115 nM for adult and embryonic receptors, respectively); increases apoptosis in HUVEC cells; decreases proliferation of HepG2 and HUVEC cells in vitro; reduces the magnitude of electrically-evoked twitch tensions in isolated rat extensor digitorum longus and soleus sciatic nerve-muscle preparations; blocks electrically-evoked muscle twitches in anesthetized rabbits (ED95 = 0.04 mg/kg)

Formal name: (1R,1’R,2R,2’R)-2,2′-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium, dibenzenesulfonate

Synonyms: 

Molecular weight: 1,243.50

CAS: 96946-42-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cancer|Angiogenesis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Neuroscience

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