A TLR8 agonist; increases the production of TNF-α and IL-12 in human PBMCs (EC50s = 140 and 120 nM

Motolimod – 5 mg

Brand:
Cayman
CAS:
926927-61-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Motolimod is an agonist of toll-like receptor 8 (TLR8).{36954} It increases the production of TNF-α and IL-12 in human peripheral blood mononuclear cells (PBMCs; EC50s = 140 and 120 nM, respectively), monocytes, and myeloid dendritic cells. Motolimod also increases IFN-γ production in natural killer (NK) cells and increases cytolysis in K562 NK cell-sensitive leukemia cells when used at concentrations of 167 and 500 nM for 48 hours. It increases plasma levels of a group of human cytokines, including IL-6, IL-12p70, TNF-α, MCP-1, and MIP-1β, in NOD-scid IL2rynull (NSG) mice reconstituted with human immune system (NSG-HIS) when administered at doses of 1.5 and 15 mg/m2.{36953} Motolimod, when used in combination with pegylated liposomal doxorubicin (PLD), reduces tumor growth and increases tumor infiltration of monocytes and T cells in an ovarian cancer NSG-HIS mouse model.  

 

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SKU: 22952 - 5 mg Category:

Description

A TLR8 agonist; increases the production of TNF-α and IL-12 in human PBMCs (EC50s = 140 and 120 nM, respectively), monocytes, and dendritic cells; increases cytolysis in K562 NK cell-sensitive leukemia cells at 167 and 500 nM for 48 hours; increases plasma levels of a group of human cytokines , including IL-6, IL-12p70, TNF-α, MCP-1, and MIP-1β, in NSG-HIS mice at 1.5 and 15 mg/m2; reduces tumor growth and increases tumor infiltration of monocytes and T cells in an ovarian cancer NSG-HIS mouse model

Formal name: 2-amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide

Synonyms:  VTX-2337

Molecular weight: 458.6

CAS: 926927-61-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition

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