A selective inhibitor of Epac2 (IC50 = 300 nM); inhibits Epac2 guanine nucleotide exchange activity; does not inhibit Epac1-mediated Rap1-GDP exchange activity or cAMP-mediated PKA activation in vitro; blocks stimulation of Epac2

HJC0350 – 5 mg

Brand:
Cayman
CAS:
885434-70-8
Storage:
-20
UN-No:
Non-Hazardous - /

HJC0350 is a selective inhibitor of exchange protein directly activated by cAMP 2 (Epac2) with an IC50 value of 300 nM for competition with 8-NBD-cAMP binding.{39180} It inhibits Epac2 guanine nucleotide exchange activity but does not inhibit Epac1-mediated Rap1-GDP exchange or cAMP-mediated protein kinase A (PKA) activation in vitro, indicating it is selective for Epac2 at a concentration of 25 μM. HJC0350 also blocks stimulation of Epac2, but not Epac1, by 007-AM in HEK293 cells.  

 

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SKU: 22949 - 5 mg Category:

Description

A selective inhibitor of Epac2 (IC50 = 300 nM); inhibits Epac2 guanine nucleotide exchange activity; does not inhibit Epac1-mediated Rap1-GDP exchange activity or cAMP-mediated PKA activation in vitro; blocks stimulation of Epac2, but not Epac1, by 007-AM in HEK293 cells

Formal name: 2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole

Synonyms: 

Molecular weight: 277.4

CAS: 885434-70-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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