An inhibitor of tubulin polymerization (IC50 = 0.53 µM); arrests the cell cycle at the G2/M transition (IC50 = 92 nM); preferentially cytotoxic to cycling cells; has antiproliferative activity in various cancer cell lines (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM); reduces tumor growth in a mouse xenograft model of human amelanoic melanoma at doses of 200 and 400 mg/kg

D-64131 – 50 mg

Brand:
Cayman
CAS:
74588-78-6
Storage:
-20
UN-No:
Non-Hazardous - /

D-64131 is an antimitotic agent that inhibits polymerization of microtubules with an IC50 value of 0.53 µM in a radioligand binding assay using purified tubules from bovine brain.{39215} It arrests the cell cycle at the G2/M transition (IC50 = 92 nM) and is preferentially cytotoxic to cycling cells. It has antiproliferative activity in cancer cell lines derived from various tissues and organs (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM). D-64131 (200 and 400 mg/kg) is also efficacious in reducing tumor growth in a mouse xenograft model of human amelanoic melanoma.  

 

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SKU: 22944 - 50 mg Category:

Description

An inhibitor of tubulin polymerization (IC50 = 0.53 µM); arrests the cell cycle at the G2/M transition (IC50 = 92 nM); preferentially cytotoxic to cycling cells; has antiproliferative activity in various cancer cell lines (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM); reduces tumor growth in a mouse xenograft model of human amelanoic melanoma at doses of 200 and 400 mg/kg,

Formal name: (5-methoxy-1H-indol-2-yl)phenyl-methanone

Synonyms: 

Molecular weight: 251.3

CAS: 74588-78-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Multidrug Resistance

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