Description
A competitive inhibitor of DNA ligases (IC50s = 10 and 10 µM for human DNA ligase I and human DNA ligase IIIβ); blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents; inhibits mitochondrial DNA ligase IIIα and induces the production of ROS and apoptosis in cancerous, but not non-malignant, cells; does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM; cytotoxic in vitro
Formal name: N-(3,5-dibromo-4-methylphenyl)-glycine, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide
Synonyms:
Molecular weight: 486.1
CAS: 325970-71-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair|DNA Ligase||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis
