A potent LRRK2 inhibitor (IC50 = 4.76 nM for the human recombinant kinase); inhibits LRRK2G2019S (IC50 = 6.87 nM); reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons

CZC-25146 – 1 mg

Brand:
Cayman
CAS:
1191911-26-8
Storage:
-20
UN-No:
Non-Hazardous - /

CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase).{32556} It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.  

 

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SKU: 22931 - 1 mg Category:

Description

A potent LRRK2 inhibitor (IC50 = 4.76 nM for the human recombinant kinase); inhibits LRRK2G2019S (IC50 = 6.87 nM); reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons

Formal name: N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide

Synonyms: 

Molecular weight: 488.5

CAS: 1191911-26-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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