Description
An antibiotic with antimycobacterial activity; targets mycobacterial cell wall synthesis by inhibiting DprE1; active against various Mycobacterium species in vitro, including M. smegmatis, M. bovis, and M. tuberculosis (MICs = 4, 2, and 1 ng/ml, respectively), as well as the actinobacterium N. brasiliensis (MIC50 = 0.125 μg/ml); active against M. tuberculosis in RAW 264.7 murine macrophages (MIC = M. tuberculosis cells in lung and spleen in a mouse model of chronic tuberculosis infection at 37.5 or 300 mg/kg for four weeks
Formal name: 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
Synonyms:
Molecular weight: 431.4
CAS: 1161233-85-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis
