A positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4; EC50 = 1.1 µM in a calcium mobilization assay); a positive allosteric modulator of mGluR6 (EC50 = 6.8 µM) and an antagonist of mGluR5 (IC50 = 17.9 µM); binds to monoamine oxidase A (MAO-A) and MAO-B (Kis = 8.5 and 7.2 µM

VU0364770 – 25 mg

Brand:
Cayman
CAS:
61350-00-3
Storage:
-20
UN-No:
Non-Hazardous - /

VU0364770 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4; EC50 = 1.1 µM in a calcium mobilization assay).{45499} It is also a positive allosteric modulator of mGluR6 (EC50 = 6.8 µM) and an antagonist of mGluR5 (IC50 = 17.9 µM). VU0364770 binds to monoamine oxidase A (MAO-A) and MAO-B (Kis = 8.5 and 7.2 µM, respectively), as well as the human norepinephrine transporter in a panel of 68 receptors, ion channels, and transporters at 10 µM. It decreases haloperidol-induced catalepsy and reduces increases in the number of premature reactions in response to a light cue, indicating improved attentional control, in a 6-hydroxydopamine (6-OHDA; Item No. 25330) rat model of Parkinson’s disease when administered at a dose of 56.6 mg/kg.  

 

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Description

A positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4; EC50 = 1.1 µM in a calcium mobilization assay); a positive allosteric modulator of mGluR6 (EC50 = 6.8 µM) and an antagonist of mGluR5 (IC50 = 17.9 µM); binds to monoamine oxidase A (MAO-A) and MAO-B (Kis = 8.5 and 7.2 µM, respectively), as well as the human norepinephrine transporter in a panel of 68 receptors, ion channels, and transporters at 10 µM; decreases haloperidol-induced catalepsy and reduces increases in the number of premature reactions in response to a light cue, indicating improved attentional control, in a 6-OHDA rat model of Parkinson’s disease at 56.6 mg/kg

Formal name: N-(3-chlorophenyl)-2-pyridinecarboxamide

Synonyms: 

Molecular weight: 232.7

CAS: 61350-00-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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