A GAT-1 inhibitor (IC50 = 49 nM); inhibits seizures induced by DMCM in mice (ED50 = 1.2 mg/kg

Tiagabine (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
145821-59-6
Storage:
-20
UN-No:
Non-Hazardous - /

Tiagabine is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 49 nM for GAT-1 expressed in CHO cells).{40522} It inhibits seizures induced by DMCM in mice (ED50 = 1.2 mg/kg, i.p.).{40519} Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin (Item Nos. 10008346 | 22910) to delay pain responses in mice in the hot plate test.{40520,40521} Formulations containing tiagabine have been used as adjunctive therapies in the treatment of partial seizures.  

 

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SKU: 22926 - 10 mg Category:

Description

A GAT-1 inhibitor (IC50 = 49 nM); inhibits seizures induced by DMCM in mice (ED50 = 1.2 mg/kg, i.p.); reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg; acts synergistically with gabapentin to delay pain responses in mice in the hot plate test

Formal name: (3R)-1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid, monohydrochloride

Synonyms:  ABT-569

Molecular weight: 412

CAS: 145821-59-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Pain Research||Research Area|Neuroscience|Seizure Disorders

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