Description
A multi-targeted anxiolytic drug with neuroprotective activities; binds to the sigma-1, melatonin MT1, and MT3 receptors, as well as MAO-A (Kis = 5.9, 160, 0.97, and 3.6 µM, respectively, in a radioligand binding assay); decreases the latency to enter, as well as increases the number of entries into and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity in passive stress-coping BALB/c, but not active stress-coping C57BL/6, mice at 5 mg/kg; decreases stroke volume and neuronal and oligodendroglial cell death in the brain in a rat model of ischemia induced by MCAO at 0.3 and 3 mg/kg
Formal name: 6-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole, monohydrochloride
Synonyms: SM-346
Molecular weight: 343.9
CAS: 173352-39-1
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Neuroprotection|Ischemia
