A tropic hormone that stimulates TSH and prolactin release; binds to the human and rat TRHR (IC50s = 25 and 198 nM

Thyrotropin-Releasing Hormone – 250 mg

Brand:
Cayman
CAS:
24305-27-9
Storage:
-20
UN-No:
Non-Hazardous - /

Thyrotropin-releasing Hormone (TRH) is a tropic hormone that stimulates release of thyroid-stimulating hormone (TSH) and prolactin.{41462} It binds to the human TRH receptor (TRHR) expressed in CHO cells and to rat TRHR in rat brain membranes (IC50s = 25 and 198 nM, respectively).{41463,41464} TRH (1 μM) decreases polyphosphoinositide and increases arachidonic and oleic acid diacylglycerol incorporation into lipids of GH3 rat pituitary tumor cells.{41465} In vitro, it dose-dependently increases TSH release from rat anterior pituitary slices and prolactin release from cultured anterior pituitary cells.{41466,41467} In vivo, TRH (0.01 mg/kg) increases TSH and prolactin plasma levels in rats.{41462}  

 

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SKU: 22917 - 250 mg Category:

Description

A tropic hormone that stimulates TSH and prolactin release; binds to the human and rat TRHR (IC50s = 25 and 198 nM, respectively); it dose-dependently increases TSH release from rat anterior pituitary slices and prolactin release from cultured anterior pituitary cells; increases TSH and prolactin plasma levels in vivo in rats (0.01 mg/kg)

Formal name: 5-oxo-L-prolyl-L-histidyl-L-prolinamide

Synonyms:  pGlu-His-Pro amide|Thyroliberin|Thyrotropin-Releasing Factor|TRF|TRH|TSH-releasing Hormone

Molecular weight: 362.4

CAS: 24305-27-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones||Research Area|Endocrinology & Metabolism|Reproductive Biology

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