Description
A small molecule CD4 mimetic; inhibits gp120 and CD4 interaction, preventing HIV from entering cells; inhibits infection of PM1/CCR5 cells from lab isolates of the HIV-1 strains IIIB (X4, Sub B) and 89.6 (dual, Sub B) (IC50s = 23 and 41 µM, respectively); inhibits infection of PM1/CCR5 cells from clinical isolates of the fTOI (R5, Sub B) and KYAG strains (R5, Sub B) (IC50s = 16 and 51 µM, respectively); inhibits HIV-1 infection of TZM-bl cells (IC50 = 8.4 µM); reduces viability of mock-infected PM1/CCR5 cells with cytotoxic concentration (CC50) values of 260 µM
Formal name: N1-(4-methylphenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-ethanediamide
Synonyms:
Molecular weight: 317.4
CAS: 144217-65-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS
