An alkaloid with diverse biological activities; inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro; inhibits the development of LPS-induced hepatitis in a dose-dependent manner in mice; reduces production of HBsAG and HBeAG in vitro (IC50s = 0.75 and 3.35 mg/ml

Matrine – 1 g

Brand:
Cayman
CAS:
519-02-8
Storage:
-20
UN-No:
Non-Hazardous - /

Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro.{38197} In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner.{38198} Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B.{38199} In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner.{38200} Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.{38201}  

 

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SKU: 22901 - 1 g Category:

Description

An alkaloid with diverse biological activities; inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro; inhibits the development of LPS-induced hepatitis in a dose-dependent manner in mice; reduces production of HBsAG and HBeAG in vitro (IC50s = 0.75 and 3.35 mg/ml, respectively); inhibits viral replication in a duck model of hepatitis B; inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner; inhibits proliferation of melanoma, breast, and colon cancer cells (IC50s = 0.769-2.758 mg/ml),

Formal name: (7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one

Synonyms:  NSC 146051|NSC 318810

Molecular weight: 248.4

CAS: 519-02-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer||Research Area|Cardiovascular System|Heart||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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