A quinazolinone alkaloid with diverse biological activities; inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM

Rutaecarpine – 5 mg

Brand:
Cayman
CAS:
84-26-4
Storage:
-20
UN-No:
Non-Hazardous - /

Rutaecarpine is a quinazolinone alkaloid originally isolated from E. rutaecarpa that has diverse biological activities.{36146} It inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM, respectively) and is selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 µM, for COX-1 and COX-2, respectively).{36144} It slows the growth of cancer cells in vitro with GI50 values of 8.41-31.6 µM.{36146} It also has cardiovascular properties, inducing dose-dependent vasodilation (0.1-10 µM) of precontracted isolated rat aorta and inhibiting platelet aggregation.{36143} In addition, rutaecarpine (80 mg/kg) decreases plasma levels of caffeine in rat by inducing its metabolism through the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2E1.{36145}  

 

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SKU: 22897 - 5 mg Category:

Description

A quinazolinone alkaloid with diverse biological activities; inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM, respectively); selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 µM, for COX-1 and COX-2, respectively); slows cancer cell growth in vitro (GI50s = 8.41-31.6 µM); induces vasodilation (0.1-10 µM) in isolated rat aorta; decreases plasma levels of caffeine in rat through CYP1A2 and CYP2E1 metabolism induction at a dose of 80 mg/kg

Formal name: 8,13-dihydro-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one

Synonyms:  NSC 258317

Molecular weight: 287.3

CAS: 84-26-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Cancer||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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